Coenzyme A levels influence protein acetylation, CoAlation and 4?-phosphopantetheinylation: Expanding the impact of a metabolic nexus molecule

Coenzyme A (CoA) is a key molecule in cellular metabolism including the tricarboxylic acid cycle, fatty synthesis, amino synthesis and lipid metabolism. Moreover, CoA required for biological processes like protein post-translational modifications (PTMs) acylation. levels affect amount of histone acetylation thereby modulate gene expression. direct influence on other PTMs, CoAlation 4?-phosphopantetheinylation has been relatively less addressed will be discussed here. Increased are associated with increased CoAlation, whereas decreased observed under circumstances levels. We discuss how these two PTMs can positively or negatively target proteins depending This review highlights impact modifications, their counteractive interplay far-reaching consequences thereof.